Genuine nonlocality of generalized GHZ states in many-partite systems

A set of orthogonal multipartite quantum states is said to be distinguishability-based genuinely nonlocal (also genuinely nonlocal, for abbreviation) if the states are locally indistinguishable across any bipartition of the subsystems. In this work, we study the (distinguishability-based) genuine nonlocality of the generalized GHZ states, primarily for the case when a large number of partites are considered. For the N-qubit case, we show that genuinely nonlocal subsets of the GHZ basis with cardianlity {\Theta}(2^(N/2)) exist. We also generalize this result to the cases when d > 2 is an even number

Positive-partial-transpose distinguishability for lattice-type maximally entangled states

We study the distinguishability of a particular type of maximally entangled states -- the "lattice states" using a new approach of semidefinite program. With this, we successfully construct all sets of four ququad-ququad orthogonal maximally entangled states that are locally indistinguishable and find some curious sets of six states having interesting property of distinguishability. Also, some of the problems arose from \cite{CosentinoR14} about the PPT-distinguishability of "lattice" maximally entangled states can be answered.Comment: It's rewritten. We deleted the original section II about PPT-distinguishability of three ququad-ququad MESs. Moreover, we have joined new section V which discuss PPT-distinguishability of lattice MESs for cases $t=3$ and $t=4$ . As a result, the sequence of the theorems in our article has been changed. And we revised the title of our articl

Distinguishability-based genuine nonlocality with genuine multipartite entanglement

A set of orthogonal multipartite quantum states is said to be distinguishability-based genuinely nonlocal (also genuinely nonlocal, for abbreviation) if the states are locally indistinguishable across any bipartition of the subsystems. This form of multipartite nonlocality, although more naturally arising than the recently popular "strong nonlocality" in the context of local distinguishability, receives much less attention. In this work, we study the distinguishability-based genuine nonlocality of a special type of genuinely multipartite entangled states -- the Greenberger-Horne-Zeilinger (GHZ)-like states. We first show that any 5 states of the three-qubit GHZ basis are genuinely nonlocal, while any 4 states of them are not. Then for more general tripartite systems, we present a universal bound about the cardinality for an arbitrary set of GHZ-like states to be genuinely nonlocal. Although not necessary, entanglement is believed to raise difficulty in state discrimination in many situations. In the literature, there has been lots of studies in favor of this perspective, including the efforts seeking for small nonlocal sets consisting of maximally entangled states in bipartite systems. Here in the tripartite case, where GHZ-like states are studied, we also find the existence of some small genuinely nonlocal sets: we show that the cardinality can scale down to linear in the local dimension d. This result not only substantiates the aforemention perspective in multipartite scenario, but also suggests that there might exist substantial difference between strong nonlocality and the normal distinguishability-based multipartite nonlocality.Comment: 13 pages, 1 figure, submitted to "New journal of physics" in Sep, 202

Twist-teleportation based local discrimination of maximally entangled states

In this work, we study the local distinguishability of maximally entangled states (MESs). In particular, we are concerned with whether any fixed number of MESs can be locally distinguishable for sufficiently large dimensions. Fan and Tian \emph{et al.} have already obtained two satisfactory results for the generalized Bell states (GBSs) and the qudit lattice states when applied to prime or prime power dimensions. We construct a general twist-teleportation scheme for any orthonormal basis with MESs that is inspired by the method used in [Phys. Rev. A \textbf{70}, 022304 (2004)]. Using this teleportation scheme, we obtain a sufficient and necessary condition for one-way distinguishable sets of MESs, which include the GBSs and the qudit lattice states as special cases. Moreover, we present a generalized version of the results in [Phys. Rev. A \textbf{92}, 042320 (2015)] for the arbitrary dimensional case.Comment: 7 pages, 2 figure

Cloning and molecular characterization of a mitogen-activated protein kinase gene from Poncirus trifoliata whose ectopic expression confers dehydration/drought tolerance in transgenic tobacco

The mitogen-activated protein kinase (MAPK) cascade plays pivotal roles in diverse signalling pathways related to plant development and stress responses. In this study, the cloning and functional characterization of a group-I MAPK gene, PtrMAPK, in Poncirus trifoliata (L.) Raf are reported. PtrMAPK contains 11 highly conserved kinase domains and a phosphorylation motif (TEY), and is localized in the nucleus of transformed onion epidermal cells. The PtrMAPK transcript level was increased by dehydration and cold, but was unaffected by salt. Transgenic overexpression of PtrMAPK in tobacco confers dehydration and drought tolerance. The transgenic plants exhibited better water status, less reactive oxygen species (ROS) generation, and higher levels of antioxidant enzyme activity and metabolites than the wild type. Interestingly, the stress tolerance capacity of the transgenic plants was compromised by inhibitors of antioxidant enzymes. In addition, overexpression of PtrMAPK enhanced the expression of ROS-related and stress-responsive genes under normal or drought conditions. Taken together, these data demonstrate that PtrMAPK acts as a positive regulator in dehydration/drought stress responses by either regulating ROS homeostasis through activation of the cellular antioxidant systems or modulating transcriptional levels of a variety of stress-associated genes

Patriotic Fun: Toys and Mobilization in China from the Republican to the Communist Era

This chapter explores the use of leisure to mobilize children in China from the 1910s to the early 1950s, in times of both war and peace. Drawing on normative advice, and commenting on youngsters’ reactions, it describes how ostensibly different regimes similarly deployed toys and play in order to foster children’s engagement in struggles of a political, commercial or military nature. It outlines how a variety of items - from so-called “educational” war toys to figurines and lanterns - could serve to rally children for the nation and familiarize war. The chapter argues that, although mobilization was construed as defensive, patriotic activism and acquaintance with the metaphorical or real battlefield were significant components of Chinese children’s upbringing from the beginning of the twentieth century

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Potential Molecular Mechanism of the NPPB Gene in Postischemic Heart Failure with and without T2DM

Background. This study is aimed at investigating natriuretic peptide B (NPPB) coexpression genes and their pathways involved in heart failure (HF) among patients both with and without type 2 diabetes mellitus (T2DM). Methods. The microarray dataset GSE26887, containing 19 postischemic HF patients’ peripheral blood samples (7 with T2DM and 12 without T2DM), was examined to detect the genes coexpressed with NPPB using the corr.test function in the R packet. Furthermore, using online analytical tools, we determined the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, Gene Ontology (GO) annotation, and protein-protein interaction (PPI) network of the coexpression genes. The modules and hub genes of the PPI network were then identified using the Cytoscape software. Results. In patients with T2DM, a total of 41 biological processes (BP), 20 cellular components (CC), 13 molecular functions (MF), and 41 pathways were identified. Furthermore, a total of 61 BPs, 16 CCs, 13 MFs, and 22 pathways in patients without T2DM were identified. In both groups of patients, 17 BPs, 10 CCs, 6 MFs, and 13 pathways were enriched. We also identified 173 intersectional coexpression genes (63 positively, 106 negatively, and 4 differently coexpressed in patients with and without T2DM, respectively) in both types of patients, which were enriched in 16 BPs, 8 CCs, 3 MFs, and 8 KEGG pathways. Moreover, the PPI network (containing 237 edges and 170 nodes) with the top module significantly enriched in 4 BPs (tricarboxylic acid metabolic process, citrate metabolic process, tricarboxylic acid cycle, and aerobic respiration) and 3 pathways (citrate cycle, malaria parasite metabolic pathway, and AGE-RAGE signaling pathway in diabetic complications) was constructed. DECR1, BGN, TIMP1, VCAN, and CTCF are the top hub genes. Conclusions. Our findings may elucidate the functions and roles of the NPPB gene in patients with postischemic HF and facilitate HF management